Hormone-Informed
Support.
A biologically informed approach to skin changes driven by declining hormones — for perimenopausal and postmenopausal skin.
Requires clinical assessment and prescription approval · Cancel, pause or skip anytime
- Loss of firmness
- Increased dryness
- Thinning skin
- Slower repair
Takes 5 minutes · Clinician reviews your skin · Prescription sent if approved
Skin changes after 45
for a biological reason.
Oestrogen plays a foundational role in skin structure — stimulating collagen synthesis, maintaining hydration, supporting wound healing, and regulating sebum production. As oestrogen declines through perimenopause and menopause, the downstream effects on skin are significant and distinct from normal ageing.
Standard retinoid therapy addresses many of these changes — but hormonally driven skin often requires actives that work specifically on the mechanisms that oestrogen would otherwise regulate. This add-on is designed for that gap.
-
01
Collagen Support
Oestrogen decline accelerates collagen loss significantly in the first years of menopause. Advanced collagen-support strategies complement the retinoid base to counteract this accelerated breakdown.
-
02
Firmness & Elasticity
Declining oestrogen reduces skin thickness and elastin density. The formula addresses the structural changes that cause sagging and loss of definition around the jawline and eyes.
-
03
Hydration & Repair
Oestrogen-deficient skin loses water more rapidly and repairs more slowly. The formula supports water-binding capacity and accelerates the repair mechanisms that slow with hormonal change.
-
04
Sensitivity Management
Hormonally thinning skin is more reactive and less tolerant of active treatment. This add-on is formulated to work in tandem with — not against — the skin's reduced tolerance thresholds.
Hormone-supportive actives.
Clinician-selected.
Formulation depends on your hormonal stage, skin presentation, and medical history. Your clinician selects from advanced collagen-support strategies and, where appropriate, hormone-supportive topical actives.
Estriol is a naturally occurring oestrogen with a well-established topical safety profile. Applied directly to skin, it supports collagen synthesis, improves hydration, restores skin thickness, and counters the structural thinning driven by systemic oestrogen decline. Available only by prescription.
The retinoid component accelerates cell turnover, supports collagen remodelling, and improves texture — working in parallel with estriol's structural support. Concentration is titrated by your clinician based on your skin's tolerance and hormonal stage.
Supports ceramide synthesis, reduces transepidermal water loss, and calms the redness and sensitivity common in hormonally thinning skin. A key tolerability component that allows the active ingredients to work without barrier compromise.
Restores the water-binding capacity that oestrogen previously supported. Multi-weight formulation penetrates at different skin depths — addressing both surface dryness and the deeper dermal dehydration characteristic of post-menopausal skin.
This is a medically informed formula — your full health history, current medications, and hormonal stage are reviewed before any prescription is issued. The assessment screens for contraindications and determines the appropriate formulation approach for your individual situation.
For skin that changed
and didn't come back.
If your skin shifted noticeably in your mid-40s or beyond — drier, thinner, less firm, more reactive — and standard products haven't addressed it, the cause is likely hormonal rather than cosmetic.
Perimenopausal and postmenopausal patients experiencing accelerated skin thinning, loss of firmness, increased dryness, or skin that has become notably more reactive than it was before hormonal transition.
This add-on involves a more thorough clinical assessment given the hormonal context. Your current medications, health history, and hormonal status are reviewed before any formula is prescribed.
The retinoid base supports collagen synthesis and cell turnover — the Hormone-Informed add-on addresses the additional mechanisms that hormonal decline affects. The combination is more comprehensive than either alone.
Hormonal skin changes are ongoing. This is a long-term support formula — most patients continue indefinitely as part of a complete skin health practice for the post-menopausal years.
Your prescription starts
with an assessment.
A licensed Canadian medical professional reviews your skin and health history. Takes 5 minutes to start.
every 2 months · cancel or pause anytime · add-on to Core Formula
The Hormone-Informed Support Add-On is a prescription product dispensed only following assessment and approval by a licensed Canadian medical professional. Laevo is not a pharmacy. All formulas are compounded at a licensed Canadian compounding pharmacy. Individual results vary. This page is for informational purposes only and does not constitute medical advice. This formula involves a more thorough clinical assessment given its hormonal context.